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The primary endpoint is a renal composite episode defined by a decrease in GFR 50%, end-stage renal failure, and death from a renal-cause or cardiovascular-caused death, and it is scheduled for completion in 2024

Participants switching from Zepbound to orforglipron were able to maintain prior weight loss with an average difference of 5.0 kg

Clinical trials, such as that by Falutz et al

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Activates the Vagus Nerve: This released GLP-1 then activates vagal afferent signalingthe nervous system pathway that sends "stop eating" and "manage blood sugar" signals directly to the brain